Feasibility of the Fecal Pancreas Elastase-Quick-TM Test for exocrine pancreatic function testing

Koning, F.H.M. de (2016) Feasibility of the Fecal Pancreas Elastase-Quick-TM Test for exocrine pancreatic function testing. thesis, Medicine.

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Abstract

Background: Pancreatic exocrine insufficiency (PEI) occurs in chronic pancreatitis or after pancreatic surgery. Patients are often not tested for PEI and therefore not treated. Fecal elastase-1 (FE-1) is well accepted for testing PEI. A new method, FE-1 Quick test™ (Quick test), claims to be non-invasive, slightly less expensive, easy to use and less time-consuming. The aim of this study was to evaluate the accuracy of the Quick test for exocrine pancreatic function testing compared to standard FE-1 test with ELISA (ELISA test). Methods: All patients with an indication for PEI testing were included. Indication for PEI testing was stated by the treating physician. All included patients received two tests, both the ELISA and the Quick test. Outcomes of the Quick test were scored by two observers, blinded for patients outcome. Appearance of a red line on the Quick test was considered “positive”, which meant normal exocrine pancreatic function (≥ 200 μg FE-1/g stool), absence of a red line was considered “negative, which meant PEI (< 200 μg FE-1/g stool). The same cut off values were considered for interpretation of the ELISA test. Results of the Quick test and ELISA were compared. The diagnostic performance of the Quick test was analyzed with Cohen’s kappa. The new test is considered accurate with a kappa value at least 0.91. Results: 44 patients were included, but data were insufficient for three patients. Therefore, a total of 41 patients (median age 61 years (IQR 54-71 years); 19 men (46.3%)) were analyzed. In 35 patients the observers agreed on outcome of the Quick test. A kappa value of 0.218 showed only fair agreement between de Quick test and the ELISA. Conclusion: The Quick test for exocrine pancreatic function testing seems inaccurate with compared with the ELISA test.

Item Type:	Thesis (Thesis)
Supervisor name:	Supervisor Groningen and Dullemen, H.M. van MD Ph D and Gastroenterologist and Dept. of Gastroenterology and Hepatology and University Medical Centre Groningen
Supervisor name:	Lekkerkerker, S.J. MD and Research fellow and Dept. of Gastroenterology and Hepatology and Academisch Medisch Centrum
Faculty:	Medical Sciences
Date Deposited:	25 Jun 2020 10:46
Last Modified:	25 Jun 2020 10:46
URI:	https://umcg.studenttheses.ub.rug.nl/id/eprint/768

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