Prins, T. (Thalina) (2016) CD103+ cells in the anti-tumour immune response in cervical cancer. thesis, Medicine.
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Abstract
Background: Tumour-infiltrating lymphocytes are associated with improved survival of cancer patients, especially when they are located in the tumour epithelium. In several malignancies, the CD103 integrin demonstrated to be a suitable marker for such intraepithelial lymphocytes, and high CD103 infiltration was associated with better prognosis. This indicates that CD103 might be a promising candidate for immunotherapy. In cervical cancer, however, the role of CD103+ cells in the anti-tumour immune response has not been investigated so far. Therefore, in this study we assessed the location and prognostic influence of CD103+ cells in cervical cancer. Methods: Immunohistochemical staining was used to determine the CD103 infiltration for 460 cervical cancer patients, in order to assess the association between CD103 infiltration and prognosis. Immunofluorescent stainings were used to determine whether CD103+ cells were indeed predominantly infiltrated within the tumour epithelium and to investigate the specific phenotypes of these cells. Results: The majority of tumours was infiltrated with CD103+ cells, although there was a large variance in the number of cells. CD103 infiltration was strongly associated with both disease-specific and disease-free survival. Furthermore, CD103+ cells were located significantly more in the tumour epithelium as opposed to the tumour-associated stroma, and were predominantly CD8+ T-lymphocytes. Conclusion: Our results demonstrate that CD103 infiltration is strongly associated with survival of cervical cancer patients and that CD103 is a suitable marker for intraepithelial tumour-infiltrating lymphocytes. This makes CD103 a promising candidate for immunotherapy in cervical cancer, although for this purpose further research is warranted, for example regarding factors influencing CD103 infiltration.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Faculty supervisor: and Nijman, Professor H.W. and Second supervisor: and Bruyn, dr. M. de and Department of Gynaecological Oncology, UMCG |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:46 |
| Last Modified: | 25 Jun 2020 10:46 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/756 |
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