Broeks, E. (Ellis) (2013) Zink als alternatief voor PYD en DPD in het bepalen van het effect van de behandeling van osteoporose. thesis, Medicine.
![[img]](https://umcg.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
BroeksE.pdf Restricted to Registered users only Download (497kB) |
Abstract
Introduction: Osteoporosis is a skeletal disorder resulting in increased fracture risk. Treatment with drugs can reduce the fracture risk. In the Slotervaartziekenhuis in Amsterdam the boneturnover markers (BTM’s) pyridinoline (PYD) and deoxypyridinoline (DPD) are measured in urine with high performance liquid chromatography (HPLC) to assess the respons to therapy. HPLC is a complex and expensive measurement. Zinc can be measured in serum and urine with the less complex and less expensive UV-spectophotometry. Zinc is essential for bone formation and is released during bone resorption. The aim of this study is to assess whether measurement of zinc can replace the measurements of PYD en DPD. Methods: In this cohort study data was collected from patients with osteoporosis or osteopenia who visited the osteoporosis clinic of the Slotervaartziekenhuis as a new patient between January 2006 and January 2011. Correlations between zinc and PYD and DPD values were measured at baseline and between the changes in values after three months and twelve months. It was tested if the values changed significantly compared to baseline. These analyses were also performed in a subcohort of 29 therapy naïve patients who started therapy at inclusion. Results: 86 patients were included, 46 were diagnosed with osteoporosis and 40 with osteopenia. After twelve months the serum zinc values of patients with osteoporosis showed a significant correlation with PYD and DPD (n=12). De values of zinc, PYD and DPD were not changed significantly compared to baseline values. In the analysis in 29 therapy naïve patients some zinc values showed a significant change after twelve months. These changes did not correlate with changes in PYD and DPD values. Conclusion: In the clinical practice in the Slotervaartziekenhuis zinc values correlated barely or not with PYD and DPD values. The study cohort is small and it was difficult to correct for influencing variables. This study does not support the introduction of zinc as a new BTM in the clinical practice. Perhaps a standardized prospective study with a longer follow-up so that changes in zinc values can be compared to clinical endpoints can provide new insights on the usefulness of zinc as BTM.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Schimmel, M. and Slotervaartziekenhuis Amsterdam and Smits, P. and ZGT Almelo |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:45 |
| Last Modified: | 25 Jun 2020 10:45 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/683 |
Actions (login required)
 |
View Item |