Wencker, C. (Corinna) (2015) Collagen-fibrin patch (TachoSil®) in prevention of lymphoceles in gynecologic cancer. thesis, Medicine.
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Abstract
Lymphoceles are a common post-surgical complication after lymphadenectomy in gynecologic malignancies. The careful sealing of lymphatic vessels to avoid the leaking of lymph fluid is usually standard in the effort to prevent lymphoceles. The current literature describes various additional methods that, however, did not show sufficient results. New evidence presented a possible new solution in the use of a collagen fibrin patch (TachoSil®) as a preventive measure. Objective of this study is to compare the effectiveness of TachoSil® – collagen fibrin patch – with standard techniques for the prevention of lymphoceles in patients with gynecologic malignancies. Data of 17 patients were collected in a non-randomized observational study. All patients underwent a lymphadenectomy as treatment for their gynecologic cancer. 10 patients received the collagen-fibrin patch for prophylaxis, 7 patients did not. Ultrasound examination on day 4, 10 and 28 after surgery were performed to look for lymphoceles. Furthermore data on baseline characteristics, cancer characteristics, operation details and post-surgical complications were collected. Lymphoceles developed in two patients of the case group and in no patients in the control group. One lymphocele was symptomatic. 80.0 % of the patients in the case group and 16.7 % of the patients in the control group suffered from a complication other than a lymphocele. Here, a significant difference between the two groups was found. Although the discrepancy between our results and previous studies could be explained by the small size of the groups, new/ future studies with a larger sample size and longer follow-up time are needed to make significant statements on the possible benefit of collagen fibrin patches in the prevention of lymphoceles.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and R.L. De Wilde, Prof. Dr. Dr. and Clinic of Gynecology, Obstetrics and Gynecological Oncology and University Hospital for Gynecology, Pius-Hospital Oldenburg and Medical Campus University Oldenburg, Germany |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:45 |
| Last Modified: | 25 Jun 2020 10:45 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/662 |
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