Bin Obaid, W.S. (2019) Hypertension as a clinical marker and a potential risk factor for cardiovascular accelerated-aging after allogeneic hematopoietic stem cell transplantation. thesis, Medicine.
Full text available on request.Abstract
Background: Patients treated with allogenic hematopoietic stem cell transplantation (alloHSCT) are at high risk of developing premature cardiovascular (CV) diseases. Hypertension is a well-known risk factor that has been linked to the development of CVD but also to subclinical organ damage, such as intima-media thickness (IMT) damage. The aim of this study is to investigate the prevalence of hypertension as a potential marker to predict both clinical CV damage and subclinical organ damage. Patients and methods: This is a prospective cross-sectional study of 114 consecutive adult patients (median age at CV evaluation: 50.95 ± 15.17) who were treated with alloHSCT for haematological diseases. Treatment-related risk factors were retrospectively collected from patient files at haematological follow-up and CV risk profile data were collected prospectively. Hypertension was defined by 24-hours ambulatory blood pressure measurement (ABPM) according to of European Society of Hypertension (ESH) 2013 guidelines. Before statistical analysis, patients were divided into normotensive and hypertensive groups and risk factors related to hypertension, transplant-related characteristics, and conventional CV risk factors were reviewed. Results: About 50 % of the included patients developed hypertension after alloHSCT and only half of them actually received therapy. Hypertensive patients had significant increase in IMT, indicative for the presence of atherosclerotic plaque (around 45 % of the hypertensive group). Traditional and treatment related risk factors seems to have limited correlation with hypertension according to our results, except for the use of Tacrolimus and presence of both acute and chronic GVHD. Conclusion: Prevalence of hypertension among alloHSCT patients is high and it is associated with subclinical IMT damage. Further study is needed, including more patients to evaluate the effect of hypertension and subclinical organ damage on development of CVD or fatal CV events
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | First Supervisor and Huls, Prof. dr. G. and Department of Hematology and Second Supervisor and Lefrandt, Dr. J.D. and Department of vascular medicine |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:45 |
| Last Modified: | 25 Jun 2020 10:45 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/636 |
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