Kessel, S. van (Susanne) (2014) Het verband tussen de neurologische conditie en cognitieve functie op 4-jarige leeftijd. thesis, Medicine.
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Abstract
Background: Minor Neurological Dysfunction (MND) is defined as the occurrence of neurological dysfunction in the absence of apparent neurological pathology. At school age neurological condition is assessed in eight domains. On the basis of the number of dysfunctional domains, neurological condition is determined. Two types of MND exist: simple MND (sMND), a suboptimal form of brain development, and complex MND (cMND), which is related to the development of learning disabilities and behavioral problems at school age. At school age, the neurocognitive relationships also differ between boys and girls. It is unknown whether these associations between MND and IQ are the same at preschool age. Aim: The primary aim of this study is to examine the relationship between neurological condition, in terms of severity and type of MND, and cognitive function, expressed as Intelligence Quotient (IQ) in 4-year-old children. Special attention is paid to sex differences. The secondary aim of this study is to explore the relationship between the severity and type of MND and IQ on a small sample of the same children at 9 years of age. Methods: We used the data of 195 four-year-old singletons (101 boys, 94 girls) of the Groningen assisted reproduction techniques (ART) cohort. 22 singletons (12 boys, 10 girls) of this study group were re-examined at the age of 9 years. To determine neurological condition and cognitive function of the 4-year-old children the Hempel resp. the Kaufman Assessment Battery for Children, second edition (K-ABC-II) were used. At the age of 9 years, the ‘MND-assessment’ and the Wechsler Abbreviated Scale of Intelligence (WASI) were used. Results: No statistically significant differences in IQ were found between the children who were classified as neurologically normal, sMND and cMND at the age of four (mean IQs resp. 106,108 and 108; p = 0,800). IQ did also not vary between the different neurological domains. The relationships between MND and IQ did not differ statistically significantly between boys and girls. At the age of nine, the average IQs were 118 for neurologically normal children, 113 and 112 for children with sMND resp. cMND. Conclusion: No relationship existed between neurological condition and cognitive function at the age of four. This held true for boys and girls. This means that MND is not an indication for early intervention to prevent learning difficulties. The first data at nine years suggested that a worse neurological outcome was associated with lower IQ. The groups were however too small for reliable statistics.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Hadders-Algra, Prof. Dr. Mijna |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:44 |
| Last Modified: | 25 Jun 2020 10:44 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/588 |
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