Dijk, M. (Marlies) (2012) Neurodevelopmental outcome at two years in relation to growth and nutrition in the neonatal period of preterm children. thesis, Medicine.
Full text available on request.Abstract
BACKGROUND. Very preterm born infants (<32 weeks) are at risk for a subnormal developmental outcome. AIM. To determine, in a large cohort of very preterm infants, born from 2004-2009 and treated in the NICU of Hospital Salesi in Ancona, the relation between growth and the neurodevelopmental outcome at two years. METHODS. This cohort study took place in the Neonatology department of hospital Salesi. Infants born between 24 and 32 weeks’ gestation, in Le Marche from 2004 – 2009 and admitted to the NICU, were included. From 2004-2009 322 infants were followed up at 2 years of age and from 2007 the BSID III was performed in 214 infants at 2 years of age. Correlation tests were used to study the association between growth and neurodevelopment outcome and the Chi² test was used to test whether proportions of children with CP are unevenly distributed amongst groups. A p-value <0.05 was considered statistically significant. RESULTS. In our cohort of very preterm infants a subnormal early neonatal growth was common. Infants with CP had an even worse neonatal growth than infants without CP. Growth correlated positively with cognitive scores, regarding weight Z-score at birth (r=0.176, p=0.011), weight Z-score at 36 weeks (r=0.175, p=0.023) and HC Z-score at 36 weeks (r=0.214, p=0.008). Small for gestational age (defined as SDS < -1.5) infants had significantly lower Bayley scores on cognitive development than appropriate for gestational age (AGA) infants at birth, 36 weeks and 2 years of age. CONCLUSIONS. Intrauterine and extrauterine growth are both associated with cognitive outcome at 2 years of age. SGA infants as a group have lower cognitive outcomes compared to AGA infants. Infants who remained appropriate for weight and HC have a better cognitive outcome than infants who showed catch-down growth.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Bos, Professor A.F. Kindergeneeskunde UMCG |
| Supervisor name: | Carnielli, Professor V.P. and Azienda Ospedaliera Universitaria and Ospedali Riuniti G. Salesi: and Neonatal Intensive Care Unit |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:43 |
| Last Modified: | 25 Jun 2020 10:43 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/428 |
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