Horenga, A. (2026) LONG-TERM FOLLOW UP OF THE OFFSPRING BORN TO MOTHERS WITH A HEART- OR LUNG TRANSPLANT. thesis, Medicine.
Full text available on request.Abstract
Background: Pregnancies after heart (HTx) and lung transplantation (LuTx) are increasing worldwide. However, data on long-term health of offspring remains scarce, particularly for children of cardiothoracic transplant recipients. Objective: To evaluate the long-term health of offspring born to mothers with a history of HTx or LuTx and to explore differences between these groups. Methods: This descriptive, cross-sectional monocentre cohort study included offspring born after maternal HTx or LuTx in the Netherlands. Data was collected through questionnaires, clinical assessments, and medical records. Outcomes included growth, cardiovascular health, general health and development, lifestyle, psychosocial functioning, and quality of life. Results: Of 23 eligible children, 9 (39.1%; aged 5.4 ± 1.3 years) were included. Eight (34.8%) haven't responded, and 6 (26.1%) declined participation. Inclusion is ongoing. Overall health, development and growth were good, without chronic diseases reported, only 1 (12.5%) child with an educational delay and 7 (87.5%) children growing within reference curves. Lifestyle was good, with 5 (62.8%) children meeting recommendations for daily physical activity. The mean systolic-blood-pressure-for-age Z-score (SBP) was +2.18 ± 0.72, with 3 (60%) children elevated (> +1SD), while the mean diastolic-blood-pressure-for-age Z�score (DBP) was +1.50 ± 0.62 with 2 (40%) elevated. Older children reported a greater impact of maternal transplantation with increased awareness of maternal health and periodic stress. No consistent differences were observed between HTx and LuTx offspring. Conclusion: Long term health appears to be reassuring. Elevated blood pressure and increasing psychosocial impact with age require further study, and larger cohorts are needed to confirm these findings.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Jong, : M.F.C. de |
| Faculty: | Medical Sciences |
| Date Deposited: | 14 Oct 2026 13:36 |
| Last Modified: | 14 Oct 2026 13:36 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3966 |
Actions (login required)
 |
View Item |