Dagal, E. (Essam) (2015) Symptomatic Pulmonary Embolism post DIEP Mamma Reconstruction : determining the prevalence and indentfying risks. thesis, Medicine.
![[img]](https://umcg.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
Dagal.pdf Restricted to Registered users only Download (993kB) |
Abstract
Background Symptomatic pulmonary embolism remains a significant cause of morbidity and mortality in abdominal flap breast reconstruction surgery, especially when using the deep inferior epigastric perforator (DIEP) flap method. Previous research has investigated the incidence and possible risk factors associated with pulmonary embolism. However, more research is warranted to identify variables that are associated with pulmonary embolism and therefore improve thromboprophylaxis. We estimated the incidence of pulmonary embolism and possible predictors of its occurrence following DIEP breast reconstruction in a sample of participants living in the north of the Netherlands. Methods A retrospective cohort study was conducted. Patients undergoing DIEP flap breast reconstruction at the University Medical Center Groningen (UMCG), between January 2005 and January 2015 were selected. All patients received thromboprophylaxis therapy. We investigated whether the following variables were associated with the occurrence of pulmonary embolism: age, body mass index, exposure to chemotherapy, exposure radiotherapy, tamoxifen consumption, smoking, mobilization after the first day and presence of BRCA1 or BRCA2 gene mutations. Associations were analyzed using univariable and multivariable binary logistic regression. Results The sample consisted of 132 participants. Symptomatic pulmonary embolism was diagnosed in 8 patients (6%). We could not detect any statistically significant association between predictors and the occurrence of pulmonary embolism. We found a trend association between age and the occurrence of pulmonary embolism. Conclusion The prevalence of symptomatic pulmonary embolism in the present sample was roughly 6%. None of the investigated predictor variables was statistically significantly associated with the occurrence of pulmonary embolism. A main study limitation was the underpowered sample size. Future studies should investigate the association between these predictors and the occurrence of pulmonary embolism in larger samples.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | supervisor : and Aalst, Dr. Vera van a doctor of plastic surgery of the depar |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:42 |
| Last Modified: | 25 Jun 2020 10:42 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/391 |
Actions (login required)
 |
View Item |