Han, Matthijs (2025) Surveillance history in patients surgically treated for esophageal adenocarcinoma. thesis, Medicine.
Full text available on request.Abstract
In patients with Barrett Esophagus (BE), endoscopic surveillance is recommended to facilitate early detection and treatment of esophageal adenocarcinoma (EAC). However, robust evidence demonstrating a survival benefit remains lacking, and recent studies suggest a lower risk of progression to EAC This study aims to compare the percentage of surgically treated EAC patients with and without prior enrolment in an BE surveillance program and to evaluate their cancer stages at diagnosis We included all patients who underwent surgical treatment for EAC in the Netherlands between 2008 and 2018. Patients were identified from the Integraal Kankercentrum Nederland and surveillance history was determined using a pathology archive. Of 5,2 62 patients (84% male; mean age 64 years [SD ±9]), 97% (5, 11 4 /5,2 62 ) had EAC at initial presentation without prior surveillance, while 3% (1 48 5,2 62 ) had a history of surveillance, with a median duration of 6 years (range 1 29). Patients with a history of surveillance had significantly lower cancer stages (p<0.05): 80 % (1 18 /1 48 ) had clinical stage 1 or 2 compared to 44 % (2 ,2 31 / 11 4 ) of unscreened patients, while 14 % 2 0 /1 48 ) had stage 3 or 4 versus 52 % (2 ,67 6 / 11 4 The vast majority of patients who underwent surgical treatment for EAC presented with cancer at initial diagnosis , without prior enrollment in an BE surveillance program. Notably, cancer was less advanced in patients enrolled in an endoscopic surveillance program.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Weusten, Prof. dr. B.L.A.M. and Munster, dr. S. N. van and Boer, L. S. PhD candidate and Meijssen, Dr. M.A.C. |
| Faculty: | Medical Sciences |
| Date Deposited: | 27 Feb 2026 14:32 |
| Last Modified: | 27 Feb 2026 14:32 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3899 |
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