Boer, Welmer de (2025) Het deconditioneringsprofiel bij overgewicht: een verlaagde eerste ventilatoire drempel. thesis, Medicine.
Full text available on request.Abstract
Introduction: Overweight is a growing global issue and is associated with an increased risk of numerous diseases and premature mortality. Deconditioning may develop as a consequence of overweight. While it is well-established that this leads to a decline in maximal oxygen uptake (VO2max), the impact on first ventilatory threshold (VT1) remains unclear. To counteract deconditioning, patients with overweight are provided with exercise recommendations. However, a subset of patients with overweight achieves only minimal benefits from these recommendations. The underlying reasons behind this lack of effectiveness remain unclear. A possible explanation could be that the training stimuli are not adequately aligned with the deconditioning profile in individuals with overweight. Methods: A retrospective observational cohort study was conducted at the Sports Medicine Center of the Martini Hospital in Groningen. A total of 87 patients were included, of whom 43 had a healthy weight and 44 were classified as overweight (BMI 25). All patients underwent a maximal cardiopulmonary exercise test (CPET) on a cycle ergometer. VT1 was the primary outcome measure, while the second ventilatory threshold (VT2) and VO2max were secondary outcome measures. The means of the outcome measures and patient characteristics of the healthy weight and overweight groups were compared. Additionally, a multivariable regression analysis was performed, adjusted for confounders, to assess the effect of overweight on VT1. Results: Patients with overweight had a significantly lower mean VT1 compared to patients with a healthy weight (58.5 16.5 vs. 72.1 22.4 , p = 0.002). After adjusting for smoking and beta-blocker use, overweight was found to have a significant negative effect on VT1 (B = -12.23, p = 0.005). In addition, patients with overweight had significantly lower mean VT2 (p = 0.002), VO2max as a percentage of the predicted value (p = 0.002) and VO2max in ml/kg/min (p < 0.005). No significant difference was found between the two groups in mean VO2max expressed in L/min (p = 0.270). Conclusion: Patients with overweight generally show a lower VT1, VT2 and VO2max as a percentage of predicted VO2max compared to those with a healthy weight. A possible explanation for an insufficient training effect for people in this group is that the training intensity may be too high relative to their deconditioning profile.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Bessem, Dr. |
| Faculty: | Medical Sciences |
| Date Deposited: | 30 Jan 2026 14:03 |
| Last Modified: | 30 Jan 2026 14:03 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3885 |
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