Özkan, S. (2024) Underutilization and Low Diagnostic Accuracy of Non-Invasive Coronary Imaging in Chronic Coronary Artery Disease in the University Medical Center of Groningen A retrospective descriptive observational study. thesis, Medicine.
Full text available on request.Abstract
Background: Chest pain is a typical symptom of myocardial ischemia caused by coronary artery disease (CAD). However, in more than 80% of the patients presenting with chest pain, the problem turns out not to be related to the heart. Non-invasive cardiac imaging techniques, such as Computed Tomography Angiography (CTA), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and Single-Photon Emission Computerized Tomography (SPECT) have been frequently studied to determine the presence or absence of myocardial ischemia and/or significant coronary artery stenosis. This study aimed to analyse the daily practice and the diagnostic accuracy of non-invasive imaging techniques in comparison with coronary angiography (CAG) in the University Medical Center of Groningen (UMCG). Methods and Results: A retrospective descriptive observational study was conducted. A total of 355 symptomatic patients who underwent elective CAG for suspected and/or established chronic coronary syndrome (CCS) were included. Non-invasive cardiac imaging was performed in 59% of the total patient population before undergoing CAG. 64% of these patients received anatomical imaging (CTA) and 36% received functional imaging (MRI, PET, or SPECT). Patients who received non-invasive imaging were significantly younger and presented with atypical chest pain, and a negative coronary medical history. The Area Under the Curve (AUC) was 0.65 and 0.64 for anatomical and functional imaging, respectively. Conclusion: Non-invasive cardiac imaging techniques are underutilized in real life practice in the UMCG in patients with CCS. Moreover, CTA has been preferred to MRI, PET, and SPECT. Importantly, the diagnostic accuracy has been relatively poor, highlighting the need for more precise non-invasive imaging techniques.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Pundziute-Do Prado, Dr. G. and Lipsic, Dr. E. |
| Faculty: | Medical Sciences |
| Date Deposited: | 12 Nov 2025 13:50 |
| Last Modified: | 12 Nov 2025 13:50 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3852 |
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