Hofstra, M.J. (2024) Acute Kidney Injury following Orthotopic Liver Transplantation: Incidence, Risk Factors and Trajectory. thesis, Medicine.
Full text available on request.Abstract
Background: Reported incidence of Acute Kidney Injury (AKI) following Orthotopic Liver Transplantation (OLT) varies widely, from 5% to 94%, depending on the definitions used. AKI following OLT is associated with development of Chronic Kidney Disease (CKD) and mortality. This study aims to find the incidence of AKI and evaluate potential risk factors, such as preexisting CKD and Hepatorenal Syndrome (HRS), and the protective effect of Dual Hypothermic Oxygenated Machine Perfusion (DHOPE). Trajectory and daily severity of AKI are used to describe the course of AKI, which has not been reported before following OLT. Methods: Adult OLT recipients were included in this two-year, single-center, retrospective cohort study. AKI was defined using the complete Kidney Disease: Improving Global Outcomes (KDIGO) definition, including Urine Output (UO). Results: In total, 99 patients were included. During postoperative ICU admission, 65% of patients developed AKI. Excluding UO criteria from the AKI definition reduced the incidence to 50%. Preexisting CKD (p = 0.03) and preoperative serum creatinine (p < 0.01) were risk factors for AKI. Persistent AKI, defined as lasting more than 48 hours, was observed in 17% of patients. Conclusions: AKI remains a common complication of OLT. A considerable number of patients do not recover from AKI following OLT. Results suggesting an association between preexisting kidney dysfunction and AKI are supported by literature. These findings align with existing literature and emphasize the need for future studies to evaluate the progression from persistent AKI to CKD and its long-term impact on patient outcomes.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Koeze, J. and Smit, M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 20 Oct 2025 12:52 |
| Last Modified: | 20 Oct 2025 12:52 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3836 |
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