Zwarts, Maria (2024) De Transcutane Bilirubinemeter De validiteit in het ziekenhuis en utvoerbaarheid in de thuissituatie bij icterische pasgeborenen. thesis, Medicine.
Full text available on request.Abstract
Background: In the first days of life, 70% of newborns develop jaundice (neonatal jaundice) due to hyperbilirubinemia, of which 3.6% require phototherapy. Bilirubin is determined in the blood (serum bilirubin, TSB) or with a non-invasive transcutaneous bilirubinometer (TcB meter). Objective: Validation of the TcB meter during and after phototherapy and evaluation of the feasibility of home treatment. Methods: The babyzietgeel@home study was an observational and qualitative study, and newborns were included from October 2023 to March 2024. Patient characteristics and laboratory values were collected, parents were interviewed, and questionnaires were administered to nurses. The VAART study was a prospective observational multicenter clinical study conducted from May 2020 to September 2022 in four hospitals. Patient characteristics, treatment data, and TcB and TSB values before, during, and after phototherapy were collected. Results: Paired TcB and TSB measurements (n=386) were available for newborns (n=105). During phototherapy, TSB was overestimated by TcB covered with a mean difference (MD) of 17.2 μmol/L (LOA: -57.5 to 91.9 μmol/L), and 14.5% of TcB values fell outside the safety margin. After phototherapy, TSB was also overestimated by TcB covered (MD: 8.5 μmol/L, LOA: 56.4 to 73.4 μmol/L), and 9.5% of measurements fell outside the safety range. TcB covered and uncovered differed significantly. Forehead measurements fell within the safety margin of 50 μmol/L. The difference between bilirubin measurements before phototherapy (TcB and TSB) and during phototherapy (TcB covered and TSB) was significantly different. Parents (n=10) and nurses (n=5) reported satisfaction with the provided information, the TcB meter, and communication with the hospital, but they also suggested im-provements. Conclusion: The use of the TcB meter can be extended to use during and after phototherapy, provided measurements are taken under a bilipatch. Measuring with the TcB meter was practically feasible, and parents and caregivers were satisfied with home treatment.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Berkhof, Dr. J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 24 Feb 2025 12:22 |
| Last Modified: | 24 Feb 2025 12:22 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3806 |
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