Heus, A. (2016) Pulmonary involvement in primary Sjögren’s syndrome. thesis, Medicine.
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Abstract
Background: In previous studies in primary Sjögren’s syndrome (pSS), the prevalence of pulmonary involvement varied greatly depending on differences in inclusion criteria and definitions of pulmonary involvement. The ESSDAI has been developed for standardized assessment of the main organ involvements. Our aim was to evaluate the prevalence and types of pulmonary involvement in pSS patients and to classify the manifestations using the pulmonary domain of the ESSDAI. Methods: This retrospective cohort study included all consecutive pSS patients, fulfilling the AECG and/or ACR classification criteria, who visited the department of Rheumatology and Clinical Immunology of the UMCG in 2015. Data were obtained from electronic patient records of the first visit in 2015. In some cases, the difference between pulmonary manifestations caused by pSS or coincidental factors remained unclear, resulting in a range of assumed to possible pulmonary involvement in pSS. Results: Of the 262 included pSS patients, 93% were female and mean age was 56 ± 15 years. Pulmonary complaints were present in 88 (34%) patients. Additional pulmonary diagnostics was performed in 225 (86%) patients. Pulmonary involvement was present in 25-39 (10-15%) pSS patients. Overall, most common was interstitial lung disease (ILD), which was present in 15 patients; especially non-specific interstitial pneumonia (NSIP). In total, 16 (6%) patients had a positive ESSDAI for the pulmonary domain; low activity (n=4), moderate activity (n=11) and high activity (n=1). Conclusion: In this cross-sectional study in daily clinical practice, pulmonary involvement was present in 10-15% of pSS patients, most common ILD. Of all pSS patients, 6% were scored as active on the pulmonary domain of the ESSDAI.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Rheumatology and Clinical Immunology and University Medical Centre Groningen and Supervisor: and Bootsma, Prof. dr. H. and Second supervisor: and Arends, Dr. S. |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:42 |
| Last Modified: | 25 Jun 2020 10:42 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/379 |
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