Poon, Jerry (2024) 1 Prolotherapy for Medial Tibial Stress Syndrome: Exploring Potential in Reducing Severity, Enhancing Activity and Alleviating Pain. thesis, Medicine.
Full text available on request.Abstract
Background and objectives: This study aims to contribute to prolotherapy research for Medial Tibial Stress Syndrome (MTSS), assessing the feasibility of a potential randomized controlled trial (RCT) on prolotherapy for MTSS. Method: A literature review involved a PubMed search recording encountered patient-reported outcome measures evaluating treatments for MTSS. A retrospective medical records review included patients with MTSS who received prolotherapy with exercise therapy or exercise therapy alone. Pain scores, retrospectively assessed before treatment and after two to four months, were compared between groups using the Chi-square test for improvements, no changes, or worsening. A pilot study assessed the effects of prolotherapy on the Medial Tibial Stress Syndrome Score (MTSSS) at two, four, six and twelve weeks. Results: In the literature review the Visual Analog Scale was encountered 15 times and the MTSSS five times. The retrospective study, including 35 patients, showed no significant difference (p=0.181) in the distribution of changes in pain score between the prolotherapy with exercise therapy group (7/12 no change, 5/12 improved) and the exercise therapy only group (8/23 no change, 15/23 improved). The pilot study, including seven patients, showed a decrease in median MTSSS at four, six and twelve weeks compared to baseline. Discussion: The retrospective study indicates no significant difference in pain improvement between prolotherapy with exercise therapy and exercise therapy alone after two to four months. Our pilot study shows promising results for prolotherapy, with no feasibility issues for a future RCT aside from a high sample size requirement. No definitive conclusions can be drawn on the effectiveness of prolotherapy on MTSS severity, pain and activity and an RCT is recommended.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Bessem, Bram and olde Heuvel, Judith and Meijerink-Huis in’t Veld, Annemiek |
| Faculty: | Medical Sciences |
| Date Deposited: | 12 Dec 2024 12:11 |
| Last Modified: | 12 Dec 2024 12:11 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3783 |
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