Dol, Cas Leendert (2024) Noten sensibilisaties en allergieën bij jonge kinderen met een sensibilisatie en/of allergie voor pinda en/of kippenei Een retrospectief onderzoek bij kinderen van 4-18 maanden oud. thesis, Medicine.
Full text available on request.Abstract
Background: Gaps in knowledge regarding the prevalence and risk factors for tree nut allergy or sensitization in young children persist. Improved understanding is crucial for timely identification of children at higher risk of developing a tree nut allergy, facilitating efficient employment of testing and prevention of allergy. Methods: This retrospective cohort study includes children aged 4 to 18 months who presented to the pediatric allergy department of the Deventer Hospital between January 2018 and December 2022 with a sensitization or allergy to peanuts and/or chicken egg. Primary outcomes were the prevalence and risk factors for hazelnut, cashew nut, or walnut sensitization and/or allergy. Secondary outcomes included the predictive values of sensitization tests for the presence of tree nut allergies. Results: In 124 children, the prevalence rates of walnut, cashew nut, and hazelnut sensitization were 9.7%, 28.2%, and 27.4%, respectively. The prevalence of walnut and cashew nut allergy was 4% and 12.9%, respectively, while hazelnut allergy was absent. Peanut allergy is identified as a significant risk factor for cashew nut sensitization (OR, 4.18; 95% CI, 1.51-11.53), cashew nut allergy (OR, 6.13; 95% CI, 1.85-20.24), and hazelnut sensitization (OR, 3.30; 95% CI, 1.21-8.99). The mean diameter of the skin prick test shows a promising predictive value for cashew nut allergy with an AUC of 0.800. Conclusion: Cashew nut allergy was most prevalent among the study group, while walnut or hazelnut allergies were rare or non-existing. Children with peanut allergy were at the greatest risk of developing a cashew nut allergy. The average diameter of the skin prick test showed promising predictive value for cashew nut allergy. Further research with larger populations is needed to confirm these findings and to develop prevention strategies for tree nut allergies in children.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Klok, Ted |
| Faculty: | Medical Sciences |
| Date Deposited: | 10 Sep 2024 11:44 |
| Last Modified: | 10 Sep 2024 11:44 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3756 |
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