Boer, A. (Anniek) (2015) Kwaliteit van leven bij patiënten met de ziekte van Parkinson met voorspelbare en onvoorspelbare motorische complicaties. thesis, Medicine.
![[img]](https://umcg.studenttheses.ub.rug.nl/style/images/fileicons/text.png) |
Text
BoerA.pdf Restricted to Registered users only Download (985kB) |
Abstract
Objective In this study we investigate the influence of motor complications on the quality of life in patients with Parkinson Disease. These motor complications involve on-off fluctuations and dyskinesias which can be predictable or unpredictable. The impact of these motor complications on quality of life is not well understood. There have been little studies on this topic, and these studies show conflicting results. The understanding of this association between motor complications and quality of life can help medics to optimize the treatment strategies and thereby minimalize the negative impact on the quality of life. Methods 378 patients of the Medical Centre Leeuwarden with Parkinson Disease were included. A total of 284 patients returned the completed questionnaire and could be used for data-analysis. The disease specific quality of life was measured with the PDQ-39. (Parkinson disease questionnaire). Data-analysis was done to determine the presence of 13 selected variables. After that, patients were classified on the basis of the presence of the motor complications in three groups: 1: uncomplicated phase, 2: complicated phase with predictable complications and 3: complicated phase with unpredictable complications. The primary outcome is the PDQ-SI, our measure for quality of life.. Results The mean PDQ-SI score in group 1 was 27.7, in group 2 36.7 and in group 3 37.1. This difference between the three groups is significant (p<0.0001). Further analysis shows that the difference in quality of life in PDQ-SI is present between group 1 and 2 and group 1 and 3, there is no difference between group 2 and 3. The PDQ scores in group 2 and 3 are significantly higher, which means a lower quality of life. In a multivariate analysis, we see that predictable complications are a significant predictor of quality of life, this is not the case with unpredictable complications. Conclusion The quality of life in the group of Parkinson’s patients with motor complications is significantly lower than the quality of life in the group without on-off fluctuations or dyskinesias. So having motor complications is a significant predictor of a worse quality of life.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Harten, dr Barbera van and Polikliniek Neurologie and Medisch Centrum Leeuwarden |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:42 |
| Last Modified: | 25 Jun 2020 10:42 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/375 |
Actions (login required)
 |
View Item |