Bliek, Thijmen (2024) Exploring an Association Between Dyslipidemia and Cardiac Dysfunction in Long Term Female Breast Cancer Survivors. thesis, Medicine.
Full text available on request.Abstract
Introduction: Breast cancer is the leading malignancy among women in the Netherlands. Due to better staging and treatment, the group of breast cancer survivors is increasing. Many patients are treated with chemo and/or radiotherapy, which are known for their cardiotoxicity. Consequently, long-term (>5 years) breast cancer survivors face increased risk of cardiovascular diseases (CVD), such as cardiac dysfunction. Currently, the Dutch guidelines of Cardiovascular Risk Management (CVRM) in the General Practice do not incorporate an assessment of previous breast cancer treatment into their risk-stratification. Our study aims to investigate if dyslipidemia is associated with cardiac dysfunction among long-term breast cancer survivors who have received chemo- and/or radiotherapy. Methods: Medical records from the hospital and the General Practitioner (GP) from 350 breast cancer survivors and matched female controls from the northern part of the Netherlands were analyzed. Dyslipidemia was defined as a: registered ICPC code T93, b: history of prescribed lipid modifying agents, or c: laboratory lipid findings. A thoracic cardiac ultrasound was performed, and blood was taken. Cardiac dysfunction was defined as a Left Ventricular Ejection Fraction (LVEF) <54%. For our analysis, a binary logistic regression was performed. Results: Dyslipidemia showed no significance on cardiac dysfunction in both univariate (OR 0,94 [95% CI 0,49-1,81]) and multivariate analysis (OR 0,87 [95% CI 0,44-1,70]), (p=0,85 vs p=0,68). A history of chemo- and/or radiotherapy was associated with cardiac dysfunction (OR 2.07 [95% CI 1,251-3,42], p = 0,01). Breast cancer survivors had higher rates of diabetes and were more frequently prescribed cardiovascular medication. Conclusion: Dyslipidemia is not associated with cardiac dysfunction among long-term breast cancer survivors.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | dr. Brandenbarg, D. and drs. Van der Wal, L.T. |
| Faculty: | Medical Sciences |
| Date Deposited: | 02 Sep 2024 11:05 |
| Last Modified: | 02 Sep 2024 11:05 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3749 |
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