BEIJERBACHT, PJOTR HIJMEN DIEDERIK (2024) The Impact of Lifestyle Factors on the Course of Depression: A Focus on Adults using SSRIs. thesis, Medicine.
Full text available on request.Abstract
Background: Depressive disorders (DD) pose a significant global health challenge. In 2030 DD is projected to be the world leading cause of disability. Some lifestyle factors have been associated with a poorer course of depression. Understanding the association between multiple lifestyle factors and the course of depressive symptoms is crucial for developing targeted interventions. Methods: This retrospective cohort study was conducted as part of the Dutch observational study of optimal, personalized antidepressant use (OPERA). It comprised 876 adult patients receiving pharmacological treatment for their current DD and aimed to explore the association between multiple lifestyle factors and symptom level as well as the course depression, i.e. 12-month remission rate. For the concerning lifestyle factors baseline depressive symptom severity, remission rates, and hazard ratios were assessed. Results: Findings show that unhealthy lifestyle behaviours, including high or low BMI, inadequate sleep duration, and lack of physical activity, were associated with greater depressive symptom severity and reduced likelihood of remission. Explorative subgroup analyses revealed age-specific nuances, with older patients (aged 60 years and above) showing no associations between lifestyle factors and depression course. Conclusion: Lifestyle factors such as sport behaviour, BMI and sleep duration are associated with depressive symptoms severity and time to remission from depression in patients using antidepressants. Further research is warranted to explore the mechanisms underlying these associations and to inform more personalized treatment approaches for depressive disorders.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | dr. Burger, H. and drs. Panjer, J.A. |
| Faculty: | Medical Sciences |
| Date Deposited: | 21 Aug 2024 11:10 |
| Last Modified: | 21 Aug 2024 11:10 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3745 |
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