Kuks, P.J.M. (2020) Neutrophilia, in blood or sputum, is not useful in phenotyping asthma. thesis, Medicine.
Full text available on request.Abstract
Introduction Data supporting neutrophilic asthma as a specific phenotype are limited yet neutrophilia remains a subject of discussion while neutrophil dominance in asthma is common. In the current study we address this issue by considering the possibility of a defined phenotype of patients with asthma and neutrophilia in sputum and/or blood in the ATLANTIS study. We focused on clinical characteristics, lung function, asthma severity and exacerbation within all asthma patients and also tailored to severe asthma patients. In addition, correlation of neutrophil levels in sputum and blood and the differences in occurrence of neutrophilia between asthma patients and healthy subjects are investigated. Method Sputum neutrophilia was defined as ≥72% sputum neutrophils and blood neutrophilia as ≥4.7*10^9 cells/L. In addition, findings were replicated on severe asthma patients of U-BIOPRED data. Results In ATLANTIS neutrophilia in sputum and blood was observed in 55/228 and 195/767 asthma subjects respectively. Levels of neutrophils in blood and sputum were weakly correlated. Sputum neutrophilia was not specific to asthma since it is also present in the healthy control group to a similar extent. No differences in the investigated variables between sputum and non-sputum neutrophilia in asthma were found. Predictors for blood neutrophilia in asthma patients were a high BMI, female gender and hyperinflation, as reflected by a higher RV/TLC. Findings on sputum and blood neutrophilia within the subanalysis in patients with more severe asthma remained generally similar. Conclusion The current study demonstrates that neutrophilic inflammation in sputum does not correspond to a clinical distinct phenotype and does not reflect asthma severity. We denote that blood neutrophilia is associated with a higher BMI, oral corticosteroid use and hyperinflation (RV/TLC).
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Dr. van den Berge, MD PhD, M. and Drs. Kole, MD, T.M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 26 Mar 2024 12:22 |
| Last Modified: | 26 Mar 2024 12:22 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3738 |
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