Kisjes, V.G. (2020) Are Allergies and Autoimmune Diseases Related to Chronic Tic Disorders and Comorbid Conditions? A Large European Study in Children and Adolescents. thesis, Medicine.
Full text available on request.Abstract
Background: Tics affect approximately 3% off all children and adolescents, however the aetiology of Chronic Tic Disorders (CTD) including Tourette Syndrome remains unclear. Allergies and autoimmune diseases appear to be related to a CTD according to existing literature, however, existing studies are contradictory and contained small study populations. Aim: To assess the relation of allergies and autoimmune diseases with CTDs, and comorbid attentiondeficit/ hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). Methods: Data were from the prospective longitudinal cohort study European Multicenter Tics in Children Study (EMTICS). The study population comprised 709 3-16-year olds with a CTD and 191 3-10-year old controls, who were first degree relatives of cases. Logistic and linear regression estimated beta values and odds ratios of the association between the presence and severity of tics, ADHD and OCD, in relation to the presence and number of allergies (allergic rhinitis and/or conjunctivitis, atopic dermatitis, asthma and other allergies) and autoimmune diseases. Results: The majority (76.7%) of incident CTD cases were boys. Presence and a higher number of allergies and autoimmune diseases was associated with higher risk of a CTD. Atopic dermatitis and allergic rhinitis and/or conjunctivitis were both suggestive of increasing the risk of a CTD, although both not significantly. Atopic dermatitis was significantly associated with 1.67 times the risk of comorbid OCD whereas OCD severity was also significantly increased. A higher number of allergies and autoimmune diseases significantly increased ADHD severity for males with a CTD. Conclusion: The findings of this study suggest an association between allergies and CTD; having more allergies and autoimmune diseases increases the risk of having a CTD whereas atopic dermatitis specifically was associated with comorbid OCD. These findings may contribute to a better understanding of the exact aetiology of CTD, therefore this study could contribute indirectly to novel treatment options in the future.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Prof. Dr. Hoekstra, P.J. and Openneer, T.J.C. and Dr. Dietrich, A. |
| Faculty: | Medical Sciences |
| Date Deposited: | 12 Dec 2023 13:19 |
| Last Modified: | 12 Dec 2023 13:19 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3732 |
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