IJpma, I.T. (2020) The effect of deep brain stimulation surgery on the psychiatric non-motor symptoms in Parkinson’s disease; an improvement in psychotic experiences. thesis, Medicine.
Full text available on request.Abstract
Background: It has been well established that deep brain stimulation (DBS) improves motor symptoms in patients with Parkinson’s disease (PD). However, the effect of DBS on non-motor symptoms (NMS) is still not fully understood. This study investigates the effect of DBS surgery with corresponding change in medication on the psychiatric NMS of PD patients. Methods: A total of 15 PD patients undergoing DBS were included for this study. Questionnaires were conducted pre-surgery and again after surgery before the stimulator was turned on. The following five questionnaires were conducted: the questionnaire for psychotic experiences (QPE), the Epworth sleepiness scale (ESS), the apathy screening scale (ASS), the questionnaire for impulsive-compulsive disorders in PD (QUIP) and the Beck depression inventory (BDI). Scores pre- and post-surgery were compared. Results: The results of this study show a 88% improvement from baseline (effect size r=0.44) of questionnaire score for psychotic experiences (p=0.008, after Benjamini-Hochberg procedure p=0.04). A 63% worsening from baseline (effect size r= -0.33) in the ASS was found (p=0.038), although after Benjamini-Hochberg procedure this change was not significant (p=0.095). The other questionnaires showed no significant change. Conclusion: This study shows a significant improvement in psychotic experiences in PD patients after DBS surgery with corresponding change in medication. This could indicate a positive role of DBS in treating medication induced psychotic experiences in PD patients.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Prof. Dr. Sommer, I.E.C. |
| Faculty: | Medical Sciences |
| Date Deposited: | 31 Oct 2023 12:33 |
| Last Modified: | 31 Oct 2023 12:33 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3718 |
Actions (login required)
 |
View Item |