Hepkema, Joris (2020) Residual Tumour in Patients with Oesophageal Cancer could Potentially be identified Before Neoadjuvant ChemoRadiation Therapy using Radiomic Features derived from 18F-PET/CT Imaging. thesis, Medicine.
Full text available on request.Abstract
Introduction Neoadjuvant ChemoRadiation Therapy (nCRT) has been shown to increase radical resection rate and 5-year overall survival. For non- or partial responders to nCRT, early detection of a high chance of poor response could aid in earlier and more accurate biopsies, resulting in more personalised treatment strategies, while for patients with pathologic complete response (pCR) surgery could potentially be omitted. Radiomic features derived from medical imaging are a promising tool for this purpose. This study combines knowledge from the radiotherapeutic, surgical and pathologic specialties. Methods 133 radiomic features derived from volumes of interest were compared between 58 patients with locally resectable oesophageal cancer, treated in the UMCG. Correlation between features was also assessed using Spearman’s test. Results 23 features were found to differ significantly between residual tumour volume (RTV) and gross tumour volume (GTV), with six clusters of features showing strong correlation. Discussion RTV showed a higher homogeneity and a coarser texture than GTV, contradictory to earlier research. The inclusion of air contained within the oesophagus in RTV is a potential explanation for this difference. Additional research with an adjusted protocol for volume delineation, which excludes air from the volumes, is required to further assess the value of these radiomic features.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Poelmann, F.B. and Plukker, J.T.M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 10 Oct 2023 11:04 |
| Last Modified: | 10 Oct 2023 11:04 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3703 |
Actions (login required)
 |
View Item |