Bögels, Ingeborg A.F (2020) Transplantations for severe polycystic liver disease, we are on the right track. thesis, Medicine.
Full text available on request.Abstract
Introduction: Polycystic liver disease (PLD) is characterized by the presence of >20 epithelial cysts in the liver. In rare cases liver volume increases up to 7,5-10 liters. In these cases, transplantation is the only effective treatment. Recent studies show that liver growth in PLD is influenced by female sex hormones. Our hypothesis is that female patients over 51, the mean menopausal age, may have had decreasing liver volumes before their transplantation. Our aim is to evaluate if female PLD patients who underwent transplantation in the UMCG in the last 20-years had a decrease in liver volume because of their post-menopausal status. Methods: Liver and kidney volumes were measured by manually tracing CT- and MRI- scans. A Fisher’s exact test was performed to determine if the number of patients with decreasing liver volumes in patients aged <51 and >51 was significantly different. Independent T-tests were used to compare annual liver growth, total liver volume (TLV) and total liver volume adjusted for height (hTLV). Results: None of the patients aged >51 had a decrease in liver volume before transplantation. There was no significant difference in the number of decreasing liver volumes in the groups aged <51 and >51 (p=0.22, Fishers exact test). Annual liver growth was significantly higher in women aged >51 (18.1% vs 2.9% p=0.019). Mean liver volumes at the time of transplantation did not differ significantly (TLV: p=0.71, hTLV: p=0.71). Conclusion: These findings reject our hypothesis that female PLD patients aged >51, already had a decrease in liver volume before they were transplanted. We can therefore conclude that these transplantations were performed with good reason.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Aapkes, Drs. S.E. and Gansevoort, Prof. dr. R.T. |
| Faculty: | Medical Sciences |
| Date Deposited: | 23 Aug 2023 11:26 |
| Last Modified: | 23 Aug 2023 11:26 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3646 |
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