Bilion, Milou (2020) The predictive power of CT-scan abnormalities in patients with mild traumatic brain injury. thesis, Medicine.
Full text available on request.Abstract
Background: Mild traumatic brain injury (mTBI) is the most common neurological disease worldwide, with an annual incidence of 600/100,000 persons. Circa 5-40% of patients experience long-term complaints. Approximately 5-15% have brain CT-scan abnormalities, but much is still unclear about their clinical consequences. This study investigates differences in hospitalisation (duration, complications) and outcome (post-traumatic complaints, mood, functional outcome) between mTBI patients with and without CT-abnormalities. Methods: Two databases were used: MST_2018 and UPFRONT. For the MST_2018 database, data on hospitalisation and complications were collected retrospectively from 155 hospitalised mTBI patients. The UPFRONT database contains 1065 mTBI patients who completed questionnaires about post-traumatic complaints (Head Injury Symptom Checklist), mood (Hospital Anxiety and Depression Scale), and outcome (Glasgow Outcome Scale Extended). Results: Patients with CT-abnormalities were more likely to be admitted >24h (χ2=8.261, p<0.01) and suffered neurological complications such as persisting headache more often (χ2=8.127, p<0.01). Six months post-injury, no differences were found between the two groups regarding post-traumatic complaints (χ2=1.311, p=0.252), anxiety (χ2=0.110, p=0.740), or depression (χ2=1.226, p=0.268). Patients with CT-abnormalities less often attained full recovery than those without (χ2=4.781, p=0.029), but duration of admission was a stronger predictor than CT-abnormalities. Conclusion: Hospitalisation of mTBI patients with CT-abnormalities differs from those without, with longer admission and more neurological complications. However, these correlations were confounded by other factors. CT-abnormalities were not related to posttraumatic complaints, anxiety, or depression. Presence of CT-abnormalities was not a strong predictor for functional outcome. In summary, this study has provided some interesting insights into the (sub)acute recovery of this very common disease.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Dorresteijn, Dr. L.D.A and de Koning, Dr. M.E. |
| Faculty: | Medical Sciences |
| Date Deposited: | 18 Aug 2023 11:31 |
| Last Modified: | 18 Aug 2023 11:31 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3634 |
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