Alhulaili, Zahraa Mahdi (2020) Risk factors and predictive scores of pancreatic fistula and other postoperative complications following pancreatoduodenectomy: A systematic review. thesis, Medicine.
Full text available on request.Abstract
Background Pancreatoduodenectomy (PD) is a challenging operation that is associated with high morbidity rates. The most serious complication is postoperative pancreatic fistula POPF. The purpose of this systematic review was to make an overview of the published literature on independent risk factors to predict POPF, and other severe complications following PD. Additionally, to summarize the previous literature on pancreas risk calculators. Methods Five databases were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses PRISMA guidelines. The quality and the risk of bias of the method were evaluated using Newcastle Ottawa Scale (NOS) criteria for non-randomised studies. Results An overall of 48 studies were included in this systematic review. Eighteen articles were related to independent risk factors for POPF following PD. Amongst these risk factors soft pancreatic (remnant) texture was the most reported factor. Moreover, 16 articles were found that developed a calculator to calculate the risk of pancreatic fistula. The remaining 14 articles were about risk factors for severe complications after PD. The risk of POPF was assessed taking into account the definition of the International Study Group for Pancreatic Fistula (ISGPF), whereas the severity of complications was graded according to the Clavien-Dindo grading system. Risk of bias was judged using the Risk of Bias In Non-randomised Studies of Interventions tool ROBINS-I after adjustment. Conclusion Soft pancreatic texture is a potential risk factor for POPF and other severe complications. While hard fibrotic pancreas is a protective factor. The main pancreatic duct MPD diameter was the most used factor when calculating the risk of POPF.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Klaase, Prof.dr. Joost |
| Faculty: | Medical Sciences |
| Date Deposited: | 26 Jul 2023 11:12 |
| Last Modified: | 26 Jul 2023 11:12 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3601 |
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