Vrijlandt, W.A.L. (2022) Low prevalence of Chronic Kidney Disease in women of reproductive age in Stockholm and reduced pregnancy rate. thesis, Medicine.
Full text available on request.Abstract
Introduction In the context of Chronic Kidney Disease (CKD), women of reproductive age deserve special consideration because of, among other things, decreased fertility and the higher risk of adverse pregnancy outcomes. Literature mentions a prevalence of 0.5-9%, but the most commonly used estimates are 3-6%. This study aims to provide accurate data on the prevalence of CKD in women of reproductive age and the pregnancy rate in this group. Methods This is a retrospective cohort study. Patients for the cohort were identified based on administrative data. Creatinine measurements and data on comorbidities were retrieved from the Stockholm CREAtinine Measurements (SCREAM) database. The Swedish Medical Birth Register provided pregnancy data. A virtual cohort, consisting of women living in the Stockholm region who were aged between 18-50 years at any moment in the period from 01-01-2006 to 31-12-2018 was created. Sequential year-blocks of 1, 2 or 3 years, within the 13-year SCREAM study period were used for sensitivity analyses. CKD was determined as requiring dialysis, having an ICD-10 code for CKD or having low eGFR (< 60 mL/min/1.72m2). Results In the virtual cohort, 857 637 women were included of whom 61% had at least one creatinine measurement. In the 3-year blocks, 581 515 to 619 772 women were included, with 35-37% having at least one creatinine measurement. Overall, the prevalence of CKD in the cohort was 0.55%, ranging from 0.22-1.08%. The results from the year-block method were consistent with those from the virtual cohort. The overall birth rates were 35.9 per 1000 in women with CKD and 43.1 per 1000 in women without CKD. Conclusion The prevalence of CKD in women of reproductive age in this cohort was 0.55%, which is much lower than the most common estimates of 3-6%. Women with a CKD diagnosis have a lower pregnancy rate than non-CKD women (35.9 vs 43.1 per 1000 per year), which raises the question if biological, psychological or a combination of both factors are causing this lower birth rate.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | de Jong, M.F.C. and Prins, J.R and Carrero, J.J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 21 Jul 2023 11:25 |
| Last Modified: | 21 Jul 2023 11:25 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3595 |
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