Boers, Mirjam (2022) Long-term adverse effects in women with breast cancer: minimal difference between mastectomy and lumpectomy with radiotherapy. thesis, Medicine.
Full text available on request.Abstract
Introduction: Breast cancer is the most common malignancy in women in the Netherlands. Two surgical options are mastectomy and lumpectomy. Lumpectomy is always combined with radiotherapy. Both surgical procedures are combined with axillary staging. Both treatment options have been extensively researched, in particular survival and short-term adverse effects. Research to long-term adverse effects is more scarce. The goal of this article is to study the long-term adverse effects (in particular after ≥10 years). Methods: Data of the hospitals MST and ZGT in the period of 2005 till 2009 were collected from the electronic patient files and analysed. Descriptive statistics, t-tests, chi-square tests and survival analyses were performed. Results: For this study 59 women were included in cohort 1 (mastectomy) and 63 in cohort 2 (lumpectomy). Fatigue, still persisting after ≥10 years (p=0.010), new angina pectoris (p=0.014), as well as new angina pectoris in the survival analysis (p=0.011) occurred significantly more often in cohort 2. No association was found between baseline characteristics, that were unevenly distributed, and time till the significant adverse effect. All other analysed adverse effects did not differ between both cohorts. Conclusion: This study showed little differences in long-term adverse effects between mastectomy and lumpectomy with radiotherapy. Only persisting fatigue after ≥10 years and new angina pectoris differed significantly. These result are useful for women with breast cancer that have to choose between the two treatments. In the future, when more women will be included in these cohorts, more solid conclusions can be drawn.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | van der Palen, Prof. Dr. J.A.M. and Stenfert Kroese, Drs. M.C. and Struikmans, Prof. Dr. H. and Jobsen, Dr. J.J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 10 Jul 2023 12:55 |
| Last Modified: | 10 Jul 2023 12:55 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3577 |
Actions (login required)
 |
View Item |