van der Lee, R.R. (2022) Effects of dietary quality and gastrointestinal complaints on symptom severity and cognition in schizophrenia spectrum disorder and bipolar disorder. thesis, Medicine.
Full text available on request.Abstract
Psychotropic treatment of schizophrenia spectrum disorder (SSD) and bipolar disease (BD) is associated with multiple side effects and has a limited effectiveness. The microbiome-gut-brain-axis (MGB-axis) was presented as a promising gateway through which dietary interventions and gastrointestinal treatment could affect psychiatric symptomatology. Studies on the effects of dietary intake and gastrointestinal complaints (GI-complaints) on SSD and BD are however limited. This study therefore aimed to further explore associations between dietary quality (DHD-scores), GI-complaints (GSRS-scores), psychiatric symptom severity (BPRS-scores), and cognition (BACS-scores). The study included 114 participants (60,5% female), diagnosed with either SSD or BD and aged 44.3±11.7 years. Subjects participated in the GUTS study, a randomized double-blind placebo-controlled trial investigating the effects of a 12-week probiotic intervention on psychiatric outcomes in subjects with bipolar and psychotic disorders. Baseline data from the GUTS study were used for analyses. Analyses were done by multiple linear regressions adjusted for diagnosis, sex, age, education, smoking and medical usage and corrected for multiple testing. Associations were shown between total dietary quality and total-, negative- and manic symptom severity; between dietary components and positive- and affective symptom components; and between GI-complaints and total-, negative- and affective symptom severity. After corrections, only the significant associations between GI-complaints and total- and affective symptoms remained. In conclusion, the associations hint towards a relationship between dietary quality, GI-complaints and psychiatric symptoms in SSD and BD. Due to the cross-sectional study design however, interpretations towards causality are limited. Future studies are encouraged to further explore possible causal relationships.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Sommer, Prof. dr. I.E.C. and Borkent, MSc J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 04 Jul 2023 11:37 |
| Last Modified: | 04 Jul 2023 11:37 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3571 |
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