Rozendal, Lynn (2022) Dietary advice consisting of unprocessed food decreases serum leptin levels in obese leptin resistant children. thesis, Medicine.
Full text available on request.Abstract
Background Childhood obesity is a growing issue worldwide. The cause is not fully understood. Previous studies stated the role of leptin, a hormone produced by adipocytes acting on the hypothalamus to induce satiety and regulate weight. However, plasma leptin levels are mostly elevated in obesity, suggesting resistance. Mechanisms of leptin resistance are unclear, but chronic low grade inflammation, associated with obesity, is one hypothesis made. Increasing attention has been given to diet quality as a potential mechanism influencing low grade inflammation. Current study investigates if a dietary advice, consisting of unprocessed foods, can be of importance in the treatment of childhood obesity. Materials and method Our advice changes a participant‟s diet within 5 steps to a diet of unprocessed foods, introducing a new step each month. Intake was assessed with the semi quantitative 177-item food frequency questionnaire. Biometric data, BMI z-score, plasma leptin levels, CRP, lipid profile and insulin were collected at baseline and after 6 months. Results 23 Participants were included. After 6 months, we found a significant decrease in plasma leptin levels of 10.47 ug/L (95% CI -18.94 – -2.54 ug/L, p = 0.013) and a significant decrease in the intake of mono- and disaccharides of 14.86 gram (95% CI -25.27 – -4.45, p = 0.007). Furthermore, a decrease in intake of all food groups en kCal was seen. Conclusion Our dietary advice causes a decrease in plasma leptin levels. Participants seem to be more sensitive to leptin, therefore having an improved feeling of satiety, leading to a decreased intake of food. Furthermore, a decrease in intake of possible harmful food products, such as soft drinks, containing high amounts of fast sugars, seems to have a greater positive effect on plasma leptin levels and BMI z-score than an increased intake of protective food products, such as vegetables.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | van der Gaag, Dr. |
| Faculty: | Medical Sciences |
| Date Deposited: | 03 Jul 2023 11:15 |
| Last Modified: | 03 Jul 2023 11:15 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3567 |
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