Maathuis, P. (2022) HOGE THERAPIETROUW BIJ ORALE IMMUNOTHERAPIE IN GEZINNEN MET EEN JONG KIND MET VOEDSELALLERGIE: EEN MIXED-METHODS STUDIE. thesis, Medicine.
Full text available on request.Abstract
Background: Oral immunotherapy (OIT) seems to be a promising treatment for young children with a food allergy. Long-term treatment with OIT produces an immunomodulatory effect that induces tolerance. To achieve long-term tolerance with OIT, adherence is essential. Since studies on adherence to OIT are lacking, this current study was designed. The aim of this study was to investigate adherence and possible determinants in families with a young child receiving OIT for food allergy. Method: Children between 9 and 24 months old with a proven food allergy, participating in the ORKA-study, and whose parents have tracked treatment adherence for at least 3 months with the Medisafe app were included. Adherence was measured based on Medisafe rapports and is quantitatively analyzed with family and allergen specific characteristics. Qualitative analysis was performed through semi-structured interviews with parents of participated children. Results: In total 50 children with single or multiple food allergies are included. Due to the multiple food allergies, the total number of OIT-trajectories was 68. Median adherence was 95.7% [IQR 91.3;98.3]. No significant difference could be demonstrated between allergens (p=0.127). Quantitative analysis showed no association between adherence and family and allergen specific determinants. The 11 interviews conducted that daily family structure, the perception of a missed dose and guidance from the ORKA-team are associated with adherence. Conclusion: The adherence rate of OIT in young children with a proven food allergy is very high, this probably underlies good explanation and guidance of the ORKA-team. In a family where the daily structure is difficult to maintain and parents don’t mind missing a dose, adherence is lower. Follow-up research in a larger study population is recommended.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Klok, dr. T |
| Faculty: | Medical Sciences |
| Date Deposited: | 13 Jun 2023 12:55 |
| Last Modified: | 13 Jun 2023 12:55 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3554 |
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