Buisman, Britt (2022) Increased Cardiovascular Biomarkers in Living Kidney Donors from Before to Three Months After Kidney Donation: Results from the TransplantLines Biobank and Cohort Study. thesis, Medicine.
Full text available on request.Abstract
Background: Reduced kidney function is associated with cardiovascular diseases (CVDs). Recent studies identified increases in left ventricular (LV) mass and cardiovascular biomarkers in living kidney donors (LKDs) within a year of kidney donation, but complete data on the relation of these biomarkers with measured glomerular filtration rate (mGFR) are needed. Methods: In this longitudinal cohort study, short-term effects of reduced kidney function on cardiovascular markers were investigated in 143 LKDs. Primary outcomes were changes between pre-donation and three months post-donation concentration of parathyroid hormone (PTH), Nterminal pro-brain natriuretic peptide (NT-proBNP), cardiac troponin T (cTnT), C-reactive protein (CRP), and hemoglobin (Hb). In multivariable linear regression analyses, the association of predonation characteristics with post-donation biomarker concentrations was investigated. Secondary outcomes were mGFR, blood pressure, heart rate, and urinary protein. Results: At three months post-donation, donors showed a 35±8% decrease in mGFR (P<0.001). After donation, donors had increased PTH (5.3[4.2; 6.5] versus 5.1[4,2; 6.0] pmol/L, P=0.021), NT-proBNP (57[33; 120] versus 43[23; 92] ng/L, P<0.001), and cTnT (9 [6;11] versus 6[5;8] ng/L, P<0.001), and decreased Hb (8.6±0.7 versus 9.1±0.8 mmol/L, P<0.001). CRP, blood pressure, heart rate, and urinary protein were unaltered. Pre-donation high-density lipoprotein (HDL) cholesterol, NT-proBNP, and age were positively associated with post-donation NTproBNP. Hypertension, and greater pre-donation age and cTnT were independent predictors of greater post-donation cTnT. Conclusion: In LKDs, reduced kidney function after donation is accompanied by increases in PTH, NT-proBNP, and cTnT, and decreased Hb. Future studies should investigate the effects of these changes on LV mass and long-term outcomes of kidney donation.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Bakker, Prof. dr. S. J. L. and van Londen, Dr. M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 24 May 2023 11:11 |
| Last Modified: | 24 May 2023 11:11 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3536 |
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