WIERSMA, B.J.B. (2023) What does the (C-)ACT score truly say about exercise induced bronchoconstriction in asthmatic children? thesis, Medicine.
Full text available on request.Abstract
Asthma is a common childhood disease and exercise induced bronchoconstriction (EIB) is a frequent and specific sign of insufficiently controlled asthma. Questionnaires are often used to evaluate asthma control. One might therefore think that these questionnaires on asthma control might relate to the presence/absence of EIB. The aim of this study was to analyze the association between such questionnaires ((Childhood) Asthma Control Test, (C-)ACT) and the presence/absence of EIB, assessed by an exercise challenge test (ECT) in cold air. Furthermore, the individual questions of these questionnaires and the patient/test descriptives were analyzed regarding the presence/absence of EIB. Although this study found a significant difference (p=0.002) regarding the association of the total (C-)ACT score and presence/absence of EIB, the distinctive power was only very moderate (area under the curve (AUC) of 0.640). The C-ACT was significant (p=0.006) in contrast to the ACT (p=0.12) and had more distinctive power (AUC of 0.67 and 0.60, respectively). Question 2 (p=0.050) and 6 (p<0.001) of the C-ACT and question 4 of the ACT (p=0.018) showed some degree of significance with an AUC of 0.60, 0.70 and 0.64, respectively. Overall, the total (C-)ACT score appears to be more effective, only question 6 of the C-ACT may have a similar/better distinctive power in comparison. Furthermore, age (p=0.049), presence of atopy (p=0.003), VAS at T=3min (p=0.036) and ECT in the summer (p=0.050), had a significantly higher average within the group with EIB. Inhalation corticosteroid usage (p=0.002) and ECT in the spring (p=0.044) had a significantly lower average within the group with EIB. Concluding, the (C-)ACT on its own is not sufficient in evaluating asthma control, as it is a very moderate predictor of presence/absence of EIB.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | THIO, DR. B. and HENGEVELD, DRS. V. and VAN DER KAMP, DRS. M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 05 May 2023 13:02 |
| Last Modified: | 05 May 2023 13:02 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3510 |
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