Liezen, Julia (2022) A translational histological study on the morphogenesis of the lingual frenulum in the first two months of pregnancy. thesis, Dentistry.
Full text available on request.Abstract
Introduction: Little is known about the early development of the lingual frenulum. A deviant morphology, such as ankyloglossia, may lead to functional problems in daily practice. This requires a verifiable and comprehensive description of the early development of this structure. The research question is: What is the morphogenesis of the lingual frenulum in the first two months of pregnancy? A better understanding of the anatomy and embryology of the lingual frenulum may contribute to a better understanding of the development of ankyloglossia and presumably to better treatment modalities. Material and methods: In a translational histological study, histological sections of 14 human embryos of Carnegie stage 17 to 23 were examined. These embryos were part of an interactive 3D atlas of human embryonic development and were selected based on their histological quality. On the histological sections, the lingual frenulum and the surrounding structures of the lingual frenulum were assessed. The ratio of the lingual frenulum to the tongue was also calculated for each embryo. Results: At Carnegie stage 18 the beginning of the emergence of lingogingival sulci bilaterally of the tongue were observed. The sulci became deeper until, at Carnegie stage 20, the lingual frenulum reached its final shape and size. From Carnegie stage 21 onwards, the tongue increased in width, but the size of the lingual frenulum remained approximately the same. Also the lingual frenulum had a tight relationship with the genioglossus muscle and the hypoglossal nerve was located just behind the lingual frenulum. Discussion: The development of the lingual frenulum takes place from day 44 to day 53 by deepening of the lingogingival sulci and relative growth difference. Because of its relationship with the genioglossus muscle and the hypoglossal nerve, a frenotomy should be performed by a trained professional who has knowledge of the anatomy of the lingual frenulum. To better review the relationship with other structures, a study based on 3D images should be carried out. In addition, a study of further development in the fetal phase could provide new perspectives.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Cune, Prof. M.S. and Slagter, Dr. K.W. and de Bakker, Dr. B.S. |
| Faculty: | Medical Sciences |
| Date Deposited: | 02 May 2023 11:33 |
| Last Modified: | 02 May 2023 11:33 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3500 |
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