Stuijt, P. (Peter) (2020) The effect of High Amplitude Low Frequency – Music Impulse Stimulation on chronic musculoskeletal pain in elderly: a multicenter randomized controlled pilot study. thesis, Human Movement Sciences.
Full text available on request.Abstract
Objective: Transcutaneous vagal nerve stimulation has analgesic potential and might be elicited by abdominally administered low-frequency vibrations. The objective was to study the effect of a combination of music and abdominally administered low-frequency vibrations on pain intensity in elderly patients with chronic musculoskeletal pain. Methods: This study was an international multicenter, randomized, prospective, double-blind, two-arm trial. Patients ≥ 65 with musculoskeletal pain for ≥ 3 months and a daily NRS score ≥ 4 were recruited at 3 centers. They were randomized to receive either a combination music and low-frequency (20-100 Hz) vibrations administered to the abdomen, or a combination with the same music but with higher frequency (200-300 Hz) vibrations administered to the abdomen. Low-frequency vibrations were expected to result in transcutaneous vagal nerve stimulation. Patients in both groups received 8 treatments of the music combined with the vibrations in 3 weeks. Follow-up measurements were conducted 6 weeks after the 8th treatment. Primary outcome was pain intensity, measured before and after each treatment session. Results: A total of 45 patients were analyzed according to the ‘intention-to-treat’ analysis. For both groups, the mean pain intensity score per patient was significantly lower after treatments than before: median of low-frequency group before treatment = 4.8 (IQR = 3.4-5.4) versus 3.9 (IQR = 2.3-5.0) after treatment, p < 0.01, r = -.49, median of high frequency group before treatment = 4.3 (IQR = 3.3-6.6) versus 3.6 (IQR = 2.5-5.3), p < 0.01, r = -.50. A multilevel linear model showed that the interaction effect of group by time did not predict pain intensity (F[1, 45.93] = 0.002, p = 0.97) when comparing pain intensity at baseline, after the last treatment and at follow-up. Discussion: Neither the low-frequency treatment group nor the high-frequency group provided clinically meaningful pain relief. It is likely that the low-frequency treatment did not elicit vagal nerve stimulation. Key words: chronic musculoskeletal pain, vagal nerve stimulation, vibro-acoustic therapy, elderly
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Lamoth, dr. C.J.C. and Soer, dr. R. |
| Faculty: | Medical Sciences |
| Date Deposited: | 20 May 2022 09:50 |
| Last Modified: | 20 May 2022 09:50 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3380 |
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