Nieboer, W. (Ward) (2021) The protective effects of high-intensity agility training plus 6-years maintenance exercising in Parkinson’s disease patients. thesis, Human Movement Sciences.
Full text available on request.Abstract
Parkinson’s disease (PD) is a neurodegenerative and progressive disease. Pharmacological interventions reduce only symptoms. High-intensity exercise training can rapidly and lastingly improve motor and non-motor PD symptoms. However, it is unclear if prolonged exercise training would maintain the reductions in symptoms. Therefore, 67 PD patients were randomly assigned to one of three groups: exercise + maintenance group (E + M), exercise only group (E) and control group (C). E + M and E completed 5 session per week for 3 weeks, a high-intensity and high-frequency agility training intervention. After these 3 weeks, E + M continued with the agility exercise program 3 times per week for 6 years, i.e., a maintenance program. Eight outcome variables were measured before and after the 3 weeks initial exercise program and then there were follow-up measurements at months 3, 6, 12, 18, 24, 36, 48, 60 and 72 after baseline. There was a group by time interaction for all eight outcomes of motor and non-motor symptoms of PD (all 8 interactions P<0.05). The initial 3 weeks of agility training improved outcomes and E + M did not further improve the benefits produced by the initial 3 weeks of high-intensity training for 6 years. In E, the effects of the 3 weeks agility training program remained visible in selected outcomes even after 6 years. In C, patients declined gradually in all outcomes over the 6 years. L-dopa increased in all three groups after 6 years, however this increase was slowed down in E + M. It is concluded that a high-intensity agility program with but not without a 6-year maintenance program reduced PD symptoms and maintained these reductions in PD symptoms.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Hortobágyi, prof. dr. T. |
| Faculty: | Medical Sciences |
| Date Deposited: | 13 May 2022 14:17 |
| Last Modified: | 13 May 2022 14:17 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3311 |
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