Kaars, R. (Robin) (2021) fMRI BOLD response during hand movement task in essential tremor and cortical myoclonus. thesis, Human Movement Sciences.
Full text available on request.Abstract
Distinguishing between different types of hyperkinetic movement disorders can be difficult, as they can occur in mixed forms and can have overlapping clinical symptoms. Neuroimaging techniques could potentially lower the margin of error in diagnostics by providing insight into the underlying brain pathology. Objective Our first aim was to gain insight into the brain areas involved in the pathophysiology of essential tremor (ET) and cortical myoclonus (CM) by examining the blood oxygenation level dependent (BOLD) signal of ET, CM, and healthy control (HC) participants. Our second aim was to determine whether it is possible to distinguish between ET, CM, and HC participants, based on their fMRI BOLD responses. Method We computed BOLD response maps for the ET (n = 9), CM (n = 12), and HC (n = 22) groups to gain insight into the pathophysiology of the disorders during a hand movement task in the fMRI scanner. Additionally, to determine whether it was possible to distinguish between the participant groups based on their BOLD response during hand movement task, we made six group comparisons; (ET vs HC, CM vs HC, and ET vs CM) for the right- and left-hand task movement respectively. Results Two comparisons between participant groups (ET > CM and CM > HC) showed increased BOLD responses. The first comparison revealed increased BOLD response in ET group compared to CM group in the ventral latero-dorsal (VLD) thalamic nuclei. The second comparison revealed increased BOLD response in the CM group compared to the HC group in the cerebellar lobules VIIb/VIII. Conclusion Results in this study might support the idea that we can make a distinction between hyperkinetic movement disorders and HC based on fMRI BOLD responses. However, these results must be interpreted with caution because they are not presented at a sufficiently stringent statistical threshold.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Smith, J. and Tuitert, I. and Dalenberg, J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 13 May 2022 12:24 |
| Last Modified: | 13 May 2022 12:24 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3303 |
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