Schipper, R. (Renata) (2016) Inflammatie en Hypofyseactiviteit in de acute fase van een herseninfarct : een prospectief cohort onderzoek. thesis, Medicine.
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Abstract
Background and purpose: Cerebral ischemia causes a complex immunological cascade. Inflammation plays an important role in this cascade, both in the central nervous system and in the periphery. Closely linked events are the activation of the hypothalamic-pituitary-adrenal axis, sympathetic nervous system and parasympathetic nervous system, probably leading to stroke-induced immunodepression (SIID). The purpose of the study was to assess whether there is a relation between an increased neuro-inflammatory response and an increased pituitary activity and the occurrence of infections. Methods: This is a prospective cohort study. Fifteen patients were analysed with a first ever ischemic stroke within a week after the onset of the symptoms. We compared patients who developed signs of inflammation after stroke with those who did not. Further, it was examined whether patients with increased pituitary activity often are associated with infections. Results: The group with signs of inflammation consisted of six patients (40%) and the group without inflammation of nine patients (60%). Between the groups no significant difference was found when considering the average of the cortisol (P=0.46), TSH (P=0.96) and FT4 values (P=0.61). In addition an increased pituitary activity was not associated with an increased incidence of infections (cortisol (P=0.53), TSH (P=0.67) and FT4 (P=0.80)). Conclusion: No relationship was found between an increased inflammatory response and increased pituitary activity as well as the occurrence of infections. However, this research has a view limitations, in order to actually exclude a relationship a study with a larger population need to be carried out.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Booij, Drs. H.A. promovenda neurologie Medisch Spectrum Twen and Hertog, Dr. H.M. den neuroloog Medisch Spectrum Twente and Palen, Prof. Dr. J.A.M. van derklinisch epidemioloog Medisch and Brusse-Keizer, Dr. M.G.J. klinisch epidemioloog Medisch Spec |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:42 |
| Last Modified: | 25 Jun 2020 10:42 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/330 |
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