Boswinkel, A.A.M. (2017) Elektronische neus en uitademingslucht: herkennen van voorstadia van dikke darmkanker. thesis, Medicine.
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Abstract
Colorectal carcinoma (CRC) is one of the main cancer related causes of death in the Netherlands, with a prevalence of 75.000. Two different premalignant colorectal lesion are known: advanced adenoma (AA) and sessile serrated adenoma/ polyps (SSA/P) with their own pathway leading to CRC. Early detection of CRC leads to improvement of survival. There are multiple ways to detect CRC and premalignant AA and SSA/P. The aim of this study is to investigate a new approach for detection of premalignant lesions: the measurement of volatile organic compounds (VOC) in exhaled air with an electronic nose. Material and methods: 369 patients with a suspicion for (pre)malignant lesion were included in this prospective cohort study. An electronic nose (AeonoseTM) was used to measure VOC in exhaled air. Breath samples were collected before and after colonic cleaning, but before colonoscopy. Based on colonoscopy and pathologic results patients were classified in a control-, premalignant- (AA and/or SSA/P), AA- or SSA/P-group. Receiver operating characteristic (ROC) graphs, sensitivity, specificity and area under the curve (AUC) were calculated with Artificial Neural Networks (ANN). Results: 25 patients per group were deblinded to build an ANN. 25 controls were compared with 25 premalignant lesions, 22 AA, 12 SSA/P, 25 AA ± polyps 5-10 mm, 17 SSA/P ± polyps 5-10 mm. Overall, premalignant lesions were distinguished from controls with a sensitivity and specificity of both 80%. Conclusion: The AeonoseTM might be a non-invasive method to detect premalignant colorectal lesions by measuring VOC in exhaled air
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Supervisor: and Kolkman, Prof. dr. J.J. and Tweede supervisor: and Jansen, M.E. and Maag-, darm- and Twente |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:41 |
| Last Modified: | 25 Jun 2020 10:41 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/316 |
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