Volkers, M.E.M. (2014) Design and testing of an MR-compatible arm cycle ergometer: Non-invasive assessment of muscle energetics during in-magnet arm and leg cycling using ³¹P-MRS. thesis, Human Movement Sciences.
Full text available on request.Abstract
Not much is known about the physiology of the human arm muscles, in contrast to leg muscles. Understanding the physiological processes in arm muscles can arise from comparing physiological responses during arm and leg cycling and might in the future improve rehabilitation and training programs for persons that depend on a wheelchair. 31Phosphorus magnetic resonance spectroscopy (31P-MRS) combined with a leg ergometer has proven to be a good method to study muscle physiological processes during leg cycling by measuring inorganic phosphate, phosphocreatine, adenosine triphosphate and pH non-invasively and in vivo in an MRI scanner. As an MR-compatible ergometer for arm cycling did not exist yet, the present pilot study aimed 1| to develop and test an MR-compatible ergometer for in-magnet human arm cycling 2| to obtain and optimize 31P-MRS data from arm muscles during arm cycling and 3| to compare 31P-MRS data obtained during arm and leg cycling in order to provide insight into the role of muscle mass in muscle physiology. Seven females participated in the present study. Arm cycling with the newly developed arm ergometer showed to be feasible in the MRI scanner with four subjects and hereafter feasibility of 31P-MRS measurements during arm cycling was demonstrated in three subjects. Within three test trials, the quality of the 31P-MRS data increased considerably. 31P-MR spectra during rest and sub-maximal and maximal arm and leg cycling were successfully obtained in one subject from whom the best arm data were acquired and showed that cycling required more effort from the m. biceps brachii compared to the m. vastus lateralis. In conclusion, a promising platform for arm cycling in the MRI scanner has been developed and successfully tested. Although interesting differences regarding muscle energetics were observed in arm cycling compared to leg cycling, future research needs to clarify whether these results are reproducible. Keywords: 31P-MR spectroscopy, skeletal muscle, musculoskeletal MR, energy metabolism
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Hettinga, dr. F.J. and Mouton, dr. L.J. and Jeneson, dr. J.A.L. |
| Faculty: | Medical Sciences |
| Date Deposited: | 06 Apr 2022 09:14 |
| Last Modified: | 06 Apr 2022 09:14 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/3058 |
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