Hettema, M. (Maaike) (2015) De invloed van bariatrische chirurgie op diabetes mellitus type 2 binnen het Centrum voor Obesitas Nederland. thesis, Medicine.
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Abstract
Background According to medical literature remission of diabetes after bariatric surgery is achieved in up to 95 percent of patients. However remission has been variably defined in these publications. A consensus statement recently defined complete (or partial) remission of diabetes as an HbA1c < 42 (or 48) mmol/mol, a fasting plasma glucose < 5,6 ( 5,6-6,9) mmol/L in the absence of pharmacological treatment. Methods In this retrospective analysis of 129 patients with diabetes 2 who underwent bariatric surgery in our centre data on HbA1c and medication prescriptions before and after 12 and 36 months were retrieved from hospital records, general practices and pharmacies. Fasting glucose values were not available and therefore skipped from the definition of remission. Complete and partial remissions were calculated as well as reduction in medication use (DDD). Results Use of oral antidiabetics was reduced from 100% to 28% and insulin use from 33% to 9%. DDD of oral antidiabetics decreased from 1.13 to 0.65 per patient after 12 months. In 96 patients with complete data on medication use and HbA1c at 12 months, complete remission was achieved in 41%. After 36 months (n =45) this was 47%. Partial remission was achieved in 15% and 11%, respectively. Conclusion Complete remission of type 2 diabetes, defined by strict criteria can be achieved in 41% after bariatric surgery after 12 months and remains stable after 36 months.
| Item Type: | Thesis (Thesis) |
|---|---|
| Supervisor name: | Heide, Drs. L.J.M. de and Medisch Centrum Leeuwarden |
| Faculty: | Medical Sciences |
| Date Deposited: | 25 Jun 2020 10:38 |
| Last Modified: | 25 Jun 2020 10:38 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/30 |
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