Aa, P.J.P. van der (2021) The influence of tobacco use and alcohol consumption at time of diagnosis on recurrence and survival in patients treated for OSCC with curative intent. thesis, Medicine.
Full text available on request.Abstract
Abstract English Introduction and objective: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, mostly associated with the risk factors tobacco use and alcohol consumption and therefore mainly diagnosed in elderly males. However, a substantial subgroup of patients with OSCC do not smoke or drink. In this study we investigate possible differences in patient characteristics, tumor characteristics and treatment outcome between the smoking and/or drinking (SD) patients and the non-smoking and non-drinking (NSND) patients with OSCC. Methods: Patients were prospectively included in the OncoLifeS databank. 144 patients surgically treated for OSCC at the University Medical Center Groningen were analyzed. Endpoints were recurrence, overall survival (OS) and disease specific survival (DSS). T-test and Chi2 test were used for all descriptive data. Univariate and multivariate survival analysis was performed for all endpoints. Results: Of the 144 patients 46 (32%) were NSND. The NSND group was older (NSND 70; SD 65 years, p=0.01) and NSND consisted of more women (F:M 2.83:1, p=0.00). The tumor site in NSND patients was predominantly located on the tongue (71.7%) and almost never on the floor of mouth (4.3%) or buccal mucosa (6.5%) (p=0.05). No significant differences in histopathological or treatment modalities were found. SD patients had a higher percentage of positive resection margins (20.4% vs. 2.2%) (p=0.01). The NSND group showed a non�significant trend towards a higher rate of recurrences (21.3% vs. 14.6%, p=0.32), comparable OS (2-year 78.6% vs. 80.8%) and DSS (2-year 81.5% vs. 86.3%). Conclusion: A distinct subgroup of NSND patients was identified in our selection of OSCC patients. Despite differences in patient and tumor characteristics, outcome was not different. Further research needs to be carried out to identify underlaying etiological factors that cause this phenomenon.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Visscher, dr. S.A.H.J. de and Bock, prof. G.H. de |
| Faculty: | Medical Sciences |
| Date Deposited: | 06 Jan 2022 09:41 |
| Last Modified: | 06 Jan 2022 09:41 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2967 |
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