Nooteboom, J. (Jet) (2021) Het effect van verlengde tocolyse bij extreme vroeggeboorte. thesis, Medicine.
Full text available on request.Abstract
This study aimed to compare the prolongation of gestational age and the maternal and neonatal outcomes between women with extreme imminent premature birth after initial tocolytics (48 hours) and after maintenance tocolytics (> 48 hours). This study retrospectively examined 60 pregnant women who were admitted between January 2010 and January 2020 with imminent premature birth with gestational age between 23+5 and 25+5 weeks GA at admission. The primary outcome was a gestational age > 26 weeks GA. Secondary outcomes were a composite of adverse neonatal outcome (perinatal mortality, BPD, neonatal sepsis, IVH > grade 2, PVE > grade 1, or NEC), birth weight and days admitted at the NICU and maternal outcome (AD during birth, prolongation of pregnancy, intra-uterine infect and caesarean section). The research question was analysed with both binary and multiple logistic regression. The number of women in the maintenance group who gave birth at a gestational age > 26 weeks was significant higher than in the non-maintenance group (p = 0.047). The remaining maternal outcome measures and the neonatal outcome were not significant different between the groups. The association between maintenance tocolysis and the chance of delivery < 26 weeks GA and the chance of adverse neonatal outcome was not significant. The results of this study are not consistent enough to draw conclusions on the effect of maintenance tocolysis on reducing extreme preterm birth and adverse neonatal outcome. Further research on this topic is urgently warranted and should focus primarly on the (long term) perinatal outcome.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Franssen, dr. M.T.M. and Woiski, dr. M. |
| Faculty: | Medical Sciences |
| Date Deposited: | 06 Jan 2022 09:22 |
| Last Modified: | 06 Jan 2022 09:22 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2963 |
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