Woudenberg, S.J. van (Suzanne) (2021) Low birth weight and elevated cardiovascular risk factors in PREVEND cohort over time: additional value of cholesterol. thesis, Medicine.
Full text available on request.Abstract
Background: Low birth weight (LBW) has been associated with an increased risk of cardiovascular diseases (CVD) in later life. Current guidelines for CVD prevention focus on classical cardiovascular risk factors. However, the importance of these risk factors in LBW adults is unknown, resulting in lack of recommendations on screening for CVD in this specific population. Aim: To investigate the changes in cardiovascular risk factors over time in adults born with LBW compared to adults born with a normal birth weight (NBW). Methods: We identified adults, aged 28-75 years, born with LBW (nwomen=508, nmen= 270) or NBW (nwomen=2711, nmen= 2264) within the PREVEND cohort. We assessed changes in blood pressure, cholesterol ratio (TC/HDL-c ratio) and fasting plasma glucose levels, the prevalence of hypertension, dyslipidemia and diabetes, and the 10-year cardiovascular risk longitudinally using 5 measurements at 3-year intervals. After stratification for sex, generalized estimating equations and logistic regressions were used for statistical analyses. Results: Marginal overall effects of LBW were observed on blood pressure in women (MDsystolic: 3.1 mmHg, MDdiastolic: 1.2 mmHg), on TC/HDL-c ratios in both sexes (MDwomen: 0.14, MDmen: 0.31) and on fasting plasma glucose levels in men (MD: 0.15 mmol/L). Additional differences were seen in blood pressure and TC/HDL-c ratios over time, within ages varying from 40 to 69 years. In parallel, LBW was associated with an increased overall risk of hypertension in women (OR: 1.3), of dyslipidemia in men (OR: 1.6) and of diabetes in both sexes (ORwomen: 1.4, ORmen: 2.0). Conclusion: Our results suggest that LBW should be considered as a cardiovascular risk factor, supporting Barker’s hypothesis of fetal origins of disease. Based on our results, we would especially stress the impact of LBW on cholesterol. Further research is needed to assess the relative importance of LBW in CVD screening compared to more well-known cardiovascular risk factors.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Groen, H. and Groenhof, T.K.J. and Lely, A.T. |
| Faculty: | Medical Sciences |
| Date Deposited: | 06 Jan 2022 09:07 |
| Last Modified: | 06 Jan 2022 09:07 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2960 |
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