Nieuwenhuizen, K.B. (Kirsten) (2021) Clostridium Difficile Infection in Paediatric Oncology and HSCT Recipients: A Retrospective Chart Review. thesis, Medicine.
Full text available on request.Abstract
Clostridium difficile infection (CDI) is one of the most common causes of diarrhea in hospitals, leading to morbidity and mortality in hospitalized patients. Paediatric cancer patients and hematopoietic stem cell transplantation (HSCT) recipients have a lot of risk factors for CDI. The aim of this study is to increase the available knowledge for detecting severe CDI, preventing recurrent CDI and treating CDI in paediatric cancer patients. Data extraction was performed between January 1st of 2010 and April 13th of 2020 from patients 18 years or under with any cancer diagnosis or HSCT who had registered CDI during or short after treatment of their cancer. A CDI is defined as diarrhea with a positive CD test from stool specimen within 72 hours of the diarrhea. A statistical analysis was carried out for clinical cure, recurrence, severe infection and global cure rates with the factors associated with these outcomes using univariate and multiple logistic regression analysis. For multiple episodes a generalized estimating equation was carried out to account for repeated episodes per patient. The clinical cure rate and relapse rate of CDI were 70.8% and 20.83% respectively. Severe infections were common (54.2%), but complications were not (25%). Most patients were treated with oral metronidazole (62.5%). The patients had generally mild symptoms. The most common diagnosis was leukemia (48%). Risk factors associated with a negative influence on clinical cure were younger age, having imaging abnormalities and inpatient status. CDI remains a common infection among paediatric oncology patients and HSCT recipients. More research needs to be done to define the risk factors and best treatment for this patient group.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Tissing, W.J.E. and Wetering, M.D. van de |
| Faculty: | Medical Sciences |
| Date Deposited: | 06 Jan 2022 07:55 |
| Last Modified: | 06 Jan 2022 07:55 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2950 |
Actions (login required)
 |
View Item |