Kleinjan, M. (Mats) (2021) Epicardial fat and left atrial function in patients with heart failure with preserved ejection fraction. thesis, Medicine.
Full text available on request.Abstract
Heart failure (HF) with preserved ejection fraction (HFpEF) is a devastating disease, with high morbidity and mortality rates. Dysfunction of the left atrium has been suggested to play a pivotal role in the pathophysiology of HFpEF patients, however, mechanisms leading to decreased left atrial function are largely unknown. Epicardial adipose tissue or epicardial fat may be one of the driving forces for worse left atrial function, as this fat depot is directly adjacent to the myocardium. Therefore, we studied the association between epicardial fat and left atrial function in patients with HFpEF. HF patients with left ventricular ejection fraction > 40% were analyzed. Left atrial volume and reservoir, booster and conduit function were assessed on cardiac magnetic resonance (CMR) imaging using dedicated software. Epicardial fat volume was quantified using short-axis view cine images on CMR. Epicardial fat was related to left atrial volume and function on CMR using linear regression analyses. We studied 57 HFpEF patients in sinus rhythm, mean age 70±8 years, 58% men. Epicardial fat was significantly associated with left atrial reservoir strain (β = -0.32, p = 0.02) and left atrial booster strain (β = -0.33, p = 0.02). In multivariable analysis, left atrial volume index remained the only independent correlate for left atrial reservoir strain (β = 0,39, p = 0.002), left atrial conduit strain (β = -0,28, p =0.03) and left atrial booster strain (β = -0,37, p = 0.02). Epicardial fat was not independently associated with left atrial function in our study. Further research is needed to better understand the pathophysiology of left atrial dysfunction in HFpEF.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Westenbrink, dr. B.D. and Woerden, drs. G. van |
| Faculty: | Medical Sciences |
| Date Deposited: | 05 Jan 2022 11:03 |
| Last Modified: | 05 Jan 2022 11:03 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2942 |
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