Ubak, K.A. (Kiki Alexandra) (2021) The predictive value of Left Atrial strain on clinical outcome in patients undergoing MitraClip implementation: the missing piece of the puzzle? thesis, Medicine.
Full text available on request.Abstract
Introduction MitraClip implementation (MCi) has become an alternative treatment for patients with Mitral Regurgitation (MR). Mostly the benefits of MCi are substantial for high risk patients suffering from severe MR, but sometimes post-operative results are still disappointing. In this study, we aim to assess the prognostic value of LA-GLS in order to enhance patient selection and timing of MCi. Method We retrospectively analyzed a cohort who underwent MCi in the UMCG between 2011 and 2020. Patients were excluded based on missing or poor quality TTE’s. LA-GLS was assessed both pre- and post-MCi. Primary outcome is all-cause death and hospitalization for heart failure within 12 months. Results We included a total of 63 patients in this study. Within one year, 16 (25.4%) patients experienced HF-hospitalization or death. There was no difference in LA-GLS in patients with or without a primary event (13.38 vs. 13.71, p =0.165). Furthermore, in Cox regression analysis, LA-GLS nor LA remodeling turned out not to be a predictor of clinical outcome. In univariate regression analysis we found pre procedural LA-GLS to be a predictor of LA remodeling (F(1,53)=9.491, p=0.003, R2 =0.152) and a lower baseline LA-GLS was associated with higher rates of improvement in LA-GLS after MCi. Conclusion In this study, LA-GLS turned out not to be a predictor of clinical outcome after MCi. Additionally, we found that LA-GLS was a predictor for LA remodeling after MCi, but LA remodeling was no predictor of clinical outcome. Future research with larger cohort is necessary to further establish the predictive value of LA-GLS in severe MR patients.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Voors, prof. dr. A. (Adriaan) and Heuvel, dr. A. van den (Ad) and Melle, dr. J. van (Joost) |
| Faculty: | Medical Sciences |
| Date Deposited: | 05 Jan 2022 10:54 |
| Last Modified: | 05 Jan 2022 10:54 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2939 |
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