Vogelaar, F. (Francien) (2021) Oculomotor assessment has construct validity, is reliable, and is age-dependent in typically developing children. thesis, Medicine.
Full text available on request.Abstract
Aim: To investigate whether oculomotor assessment according to the International Cooperative Ataxia Rating Scale’s oculomotor subscale (ICARSOCM) can contribute to quantitative ataxia assessment in children with Early Onset Ataxia (EOA) and to investigate its age-dependency. Methods: In 52 children (4-16 years of age), we determined construct validity, reliability, and age-dependency of ICARSOCM. Three independent assessors scored saccadic eye movement and ocular pursuit for ICARSOCM and the applicable Ocular Motion Score items (OMS7-10). We determined the ICARSOCM construct validity by correlation with both OMS7-10 and ICARSHAND-EYE COORDINATION (for eye movement and ataxia construct, respectively). We determined reliability by calculating Fleiss Kappa and agreement percentage. Finally, we determined and compared cross-sectional ICARSOCM and Scale for the Assessment and Rating of Ataxia (SARA, historic data) age-dependency by fitting and comparing the curves in exponential models. Results: Spearman’s correlation between ICARSOCM and OMS7-10 and between ICARSOCM and ICARSHAND-EYE COORDINATION were significant (p<0.001, interpretable as moderate and fair, respectively). The inter-rater agreement percentage of ICARSOCM was 80.8%, and Fleiss Kappa was 0.411 (p<0.001). ICARSOCM was shown to be age-dependent until 10 years old. Conclusion: ICARSOCM can be used reliably in clinical neuro-paediatric practice, and has a valid construct for eye movement parameters. Analogous to SARA ataxia rating scale parameters, we observed an association between ICARSOCM and age, reflecting the physiological maturation of the cerebellum. These data implicate that quantitative oculomotor parameters may contribute to reliable ataxia assessment in children with EOA.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Maurits, prof. dr. ir. N. (Natasha) and Sival, dr. D. (Deborah) |
| Faculty: | Medical Sciences |
| Date Deposited: | 03 Jan 2022 11:27 |
| Last Modified: | 03 Jan 2022 11:27 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2926 |
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