Wolters, J. (Jelle) (2021) Long term outcome of critically ill patients with acute kidney injury. thesis, Medicine.
Full text available on request.Abstract
Introduction: Acute kidney injury is a common problem amongst critically ill patients. It is associated with increased mortality and longer admissions. Those affected by the most severe form of acute kidney injury require renal replacement therapy. Patients in need of renal replacement therapy have higher mortality and are more likely to develop chronic kidney disease later in life. The aim of this clerkship was to study patients with acute kidney injury that required renal replacement therapy and analyse whether serum creatinine on discharge was associated with a worse renal function in the future. Methods: Patients that were treated with renal replacement therapy due to acute kidney injury were included in this analysis. Long-term follow-up of serum creatinine was obtained through electronic health records. Patients were separated in groups of low- and high serum creatinine on discharge. Renal function between these groups was compared through serum creatinine, at seven, thirty and sixty days after discharge, as well as the latest possible follow-up. Patient characteristics associated with worse renal function were also analysed. Results: Patients in the high serum creatinine group had an elevated serum creatinine at seven and thirty days compared to the low serum creatinine group (p=0.0127 and p=0.0390 respectively), but this difference was not present at the later follow-up points. The median serum creatinine was elevated above normal reference values in both groups, at the latest follow-up point. Conclusions: Serum creatinine on discharge is not associated with serum creatinine at long-term follow-up. Future studies should focus on finding methods to identify patients at-risk of developing CKD after an ICU admission.
| Item Type: | Thesis (UNSPECIFIED) |
|---|---|
| Supervisor name: | Koeze, dr. J. |
| Faculty: | Medical Sciences |
| Date Deposited: | 03 Jan 2022 10:58 |
| Last Modified: | 03 Jan 2022 10:58 |
| URI: | https://umcg.studenttheses.ub.rug.nl/id/eprint/2920 |
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